KMID : 0620920170490120002
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Experimental & Molecular Medicine 2017 Volume.49 No. 12 p.2 ~ p.2
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Nanocurcumin?pyrroloquinoline formulation prevents hypertrophy?induced pathological damage by relieving mitochondrial stress in cardiomyocytes under hypoxic conditions
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Nehra Sarita
Bhardwaj Varun Bansal Anju Chattopadhyay Pronobesh Saraswat Deepika
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Abstract
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This study investigates the therapeutic effect of a nanocurcumin formulation (NCF) containing nanocurcumin (NC) and pyrroloquinoline quinone (PQQ) on ameliorating hypoxia-induced stress in hypertrophied primary human ventricular cardiomyocytes (HVCM) under hypoxic conditions, as validated in a Sprague-Dawley rat model of chronic hypobaric hypoxia (cHH)-induced right ventricular hypertrophy (RVH). Based on our previous findings, here, we analyzed the improvement in the protective efficacy of NCF against mitochondrial damage. The electron transport chain Complexes¡¯ activities were analyzed as a chief operational center for mitochondrial homeostasis, along with key gene and protein markers for mitochondrial biogenesis, redox function, fatty acid oxidation, bio-energetic deficit and cell survival. NCF supplementation imparts cyto-protection from hypoxia-induced hypertrophy and damage in both in vitro and in vivo models while maintaining mitochondrial homeostasis better than NC and PQQ alone. This study proposes the use of NCF as a potential candidate molecule for imparting protection from high altitude-induced maladies in ascendants.
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KEYWORD
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Cardiac hypertrophy, Prognostic markers
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